- 中文别名：硫酸长春地辛
- 中文释义：硫酸长春地辛;2-bromo-1-fluoro-3-methylbenzene;3-Fluoro-2-Bromo Toluene;4-chloro-2,3-dimethylpyridine 1-oxide;2,3-Dimethyl-4-chloropyridine-N-oxide;1,3-双(二苯基磷)丙烷二氯化钯;1,3-双(二苯基膦)丙烷氯化钯;双(1,3-二苯基膦)丙基二氯化钯 (II);5-isobenzofurancarbonitrile,1,3-dihydro-1-(3-(dimet
- 英文别名：vindesine sulfate;
Vindesine Sulfate Salt;
Vindesine sulphate - cas No.：59917-39-4
- 分子式：
C43H55N5O7.H2SO4
- 分子量：852.01
- 精确分子量：851.37800
- PSA：247.80000
- InChI：InChI=1/C43H55N5O7.H2O4S/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50;1-5(2,3)4/h8-12,14,19-20,25,34-36,45,49,52-53H
- 分子结构式：
物化性质
- 外观与性状：
- 非晶形的固体
- 密度：
- 1.41 g/cm3
- 熔点：
- >250ºC
安全信息
- 外观与性状：
- 非晶形的固体
- 密度：
- 1.41 g/cm3
- 熔点：
- >250ºC
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YY8090000
- CAS REGISTRY NUMBER :
- 59917-39-4
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C43-H55-N5-O7.H2-O4-S
- MOLECULAR WEIGHT :
- 852.11
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1050 ug/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - urine volume increased
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1790 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1920 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - urine volume increased Blood - normocytic anemia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3500 ug/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - urine volume increased
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1250 ug/kg/33D-I
- TOXIC EFFECTS :
- Endocrine - other changes Blood - changes in bone marrow (not otherwise specified) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 1250 ug/kg
- SEX/DURATION :
- male 10 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 28 nmol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 38,2886,1978