- 中文别名：毒虫威
- 中文释义：毒虫畏;代草克;2-氯-1-(2,4-二氯苯基)乙烯基二乙基磷酸酯;GC-4072
- 英文别名：chlorfenvinfos;
Chlorfenvinphos;
(1Ξ)-2-chloro-1-(2,4-dichlorophenyl)ethenyl diethyl phosphate;
chlorfenvinphos;
clofenvinfos;
(EZ)-2-chloro-1-(2,4-dichlorophenyl)vinyl diethyl phosphate;
Chlorfenvinfos;
2-chloro-1-(2,4-dichlorophenyl)ethenyl diethyl phosphate - cas No.：470-90-6
- 分子式：C12H14Cl3O4P
- 分子量：359.57000
- 精确分子量：357.97000
- PSA：54.57000
- MDL：MFCD00041818
- InChI：The Key: FSAVDKDHPDSCTO-WQLSENKSSA-N
- 分子结构式：
物化性质
- 外观与性状：
- 琥珀色的液体,带有一种温和化学气味
- 密度：
- 1.373g/cm3
- 熔点：
- -23 to -19ºC
- 沸点：
- 396.5ºC at 760 mmHg
- 闪点：
- 100 °C
- 水溶解性：
- Insoluble
- 折射率：
- 1.534
- 蒸汽压：
- 3.9E-06mmHg at 25°C
- 存储条件/存储方法：
- 库房通风低温干燥,与食品原料分开储运
- 稳定性相关：
明火可燃; 受热放出有毒氧化磷、氯化物气体
安全信息
- 外观与性状：
- 琥珀色的液体,带有一种温和化学气味
- 密度：
- 1.373g/cm3
- 熔点：
- -23 to -19ºC
- 沸点：
- 396.5ºC at 760 mmHg
- 闪点：
- 100 °C
- 水溶解性：
- Insoluble
- 折射率：
- 1.534
- 蒸汽压：
- 3.9E-06mmHg at 25°C
- 存储条件/存储方法：
- 库房通风低温干燥,与食品原料分开储运
- 稳定性相关：
明火可燃; 受热放出有毒氧化磷、氯化物气体
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TB8750000
- CHEMICAL NAME :
- Phosphoric acid, 2-chloro-1-(2,4-dichlorophenyl)vinyl diethyl ester
- CAS REGISTRY NUMBER :
- 470-90-6
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 37
- MOLECULAR FORMULA :
- C12-H14-Cl3-O4-P
- MOLECULAR WEIGHT :
- 359.58
- WISWESSER LINE NOTATION :
- GR CG DYU1GOPO&O2&O2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 26400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6600 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 336 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 87 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 339 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 87 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 51 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 125 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - pigeon
- DOSE/DURATION :
- 13300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 29100 ug/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 23100 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - quail
- DOSE/DURATION :
- 148 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - fasciculations Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - domestic
- DOSE/DURATION :
- 71250 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cattle
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 13 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 420 mg/kg/12W-C
- TOXIC EFFECTS :
- Endocrine - changes in spleen weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 49 mg/kg/35W-I
- TOXIC EFFECTS :
- Cardiac - other changes Liver - other changes Kidney, Ureter, Bladder - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 182 mg/kg/26W-I
- TOXIC EFFECTS :
- Blood - changes in leukocyte (WBC) count
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50400 mg/kg/28D-I
- TOXIC EFFECTS :
- Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 14 mg/kg/17W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 697 mg/kg/7D-C
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 2100 ug/kg/12W-C
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 500 ug/plate
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 116,185,1983 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973 TOXICOLOGY REVIEW CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966- Volume(issue)/page/year: 10(3),43,1975 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989
- 毒理学数据：
口服-大鼠 LD50: 10 毫克/公斤; 口服-小鼠 LD50: 65 毫克/公斤
MSDS
| 国标编号: | 61874 |
| ＣＡＳ: | 470-90-6 |
| 中文名称: | 毒虫畏 |
| 英文名称: | Phosphosric Acid;Chlorfenvinphos |
| 别 名: | 杀螟威；2-氯-1-(2，4-二氯苯基)乙烯基二乙基磷酸酯 |
| 分子式: | C12H14Cl3O4P |
| 分子量: | 359.58 |
| 熔 点: | 167～170℃(66.7Pa) |
| 密 度: | 1.36 |
| 蒸汽压: | |
| 溶解性: | 微溶于水，但可与丙酮、乙醇、煤油、丙二醇和二甲苯混 |
| 稳定性: | 本品能被水缓慢水解，对钢、铁、黄铜等有腐蚀作用，但 |
| 外观与性状: | 本品是(Z)和(E)异构体的混合物，其中大多数是(Z)异构体，为琥珀色油状液体，(Z：E)异构体的标准比例为8.5： |
| 危险标记: | 14(有毒品) |
| 用 途: | 杀虫剂，在土壤处理时，可防治地老虎、根蝇等 |
2.对环境的影响: 毒理学资料 急性毒性：LD50117mg/kg(小鼠经口)； 20mg/kg(大鼠经口) 3.现场应急监测方法: 4.实验室监测方法: 气相色谱法，参照《分析化学手册》(第四分册，色谱分析)，化学工业出版社 气相色谱法(农作物、水果、蔬菜)《农药残留量气相色谱法》国家商检局编 5.环境标准: 欧洲经济共同体法规(1982)食物中最高残留限值 一般农作物：0.1mg/kg；特定农作物：0.05～0.5mg/kg 美国(1981)食物和饲料中容许残留限值 0.005～0.2mg/kg(特定畜产品) 6.应急处理处置方法: 急性中毒时，立即使患者脱离现场，脱去污染衣服，全身污染部位用肥皂水或碱溶液彻底清洗，如系口服者，应立即口服1～2%苏打水，或用0.2～0.5%高锰酸钾溶液洗胃，并服用片剂解磷毒(PAM)或阿托品1～2片。眼部污染可用苏打水或生理盐水冲洗。 漏应急处理：迅速撤离泄漏污染区人员至安全区，严格限制出入。切断火源。穿防毒服。切断泄漏源。小量泄漏用砂土或其它不燃材料吸附或吸收。也可大量水冲洗，洗水稀释后放入废水系统。大量泄漏：构筑围堤或挖坑收容。用泡沫覆盖降低蒸气灾害。用泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。 消防：用水、砂土、二氧化碳灭火器灭火，应注意穿戴可靠的防毒、防护用品，防止人身中毒。
分子结构与计算化学数据
分子结构数据
五、分子性质数据：
1、 摩尔折射率：81.43
2、 摩尔体积（cm3/mol）：261.8
3、 等张比容（90.2K）：671.2
4、 表面张力（dyne/cm）：43.2
5、 介电常数（F/m）：
6、 偶极距（D）：
7、 极化率（10-24cm3）：32.28