diethylene glycol

中文别名：一缩二乙二醇
中文释义：二乙二醇;二甘醇;二(羟乙基)醚;2,2\'-氧代二乙醇
英文别名：Diethylene glycol;
DEG;
2,2'-Oxydiethanol;
Bis(2-hydroxyethyl)ether
cas No.：111-46-6
分子式：
C₄H₁₀O₃
分子量：106.12
精确分子量：106.06300
PSA：49.69000
MDL：MFCD00002882
InChI：InChI:1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2
分子结构式：

物化性质

外观与性状：

透明液体

密度：

1.118 g/mL at 25 °C(lit.)

熔点：

−10 °C(lit.)

沸点：

245 °C(lit.)

闪点：

143 °C

水溶解性：

SOLUBLE

折射率：

n20/D 1.447(lit.)

蒸汽压：

0.00469mmHg at 25°C

蒸汽密度：

2.14 (vs air)

存储条件/存储方法：

1.密封于阴凉、干燥处保存。确保工作间有良好的通风设施。

2.远离火源、水源。储存的地方远离氧化剂。

稳定性相关：

1.避免与氧化物、潮湿的水分接触。

其它信息：

1.性状：无色、无臭、透明，具有吸湿性的黏稠液体，有辛辣气味，无腐蚀性。

2.沸点（ºC,101.3kPa）：245

3.熔点（ºC）：-10.5

4.相对密度（g/mL,20/4ºC）：1.118

5.相对蒸汽密度（g/mL,空气=1）：2.14

6.折射率（15ºC）：1.4490

7.折射率（20ºC）：1.4472

8.常温折射率（n²⁵）：1.446

9.黏度（mPa·s,20ºC）：35.7

10.黏度（mPa·s,25ºC）：30

11.闪点（ºC,闭口）：143

12.燃点（ºC）：229

13.蒸发热（KJ/mol,b.p.）：52.297

14.燃烧热（KJ/mol）：2380.2

15.比热容（KJ/(kg·K),20ºC,定压）：2.31

16.电导率（S/m,20ºC）：5.86×10^-7

17.蒸气压（kPa,20ºC）：<0.0013

18.体膨胀系数（K^-1,20ºC）：0.000635

19.爆炸下限（%,V/V）：0.7

20.爆炸上限（%,V/V）：22

21.溶解性：能与水、乙醇、乙二醇、丙酮、氯仿、糠醛等混溶。与乙醚、四氯化碳、二硫化碳、直链脂肪烃、芳香烃等不混溶。

22.相对密度（25℃，4℃）：1.1122

23.临界温度（ºC）：476.85

24.临界压力（MPa）：4.7

25.溶度参数(J·cm^-3)^0.5：27.775

26.vanderWaals面积（cm²·mol^-1）：8.920×10⁹

27.vanderWaals体积（cm³·mol^-1）：60.700

28.气相标准燃烧热(焓)(kJ·mol^-1)：-2432.0

29.气相标准声称热(焓)(kJ·mol^-1)：-571.2

30.液相标准燃烧热(焓)(kJ·mol^-1)：-2374.7

31.液相标准声称热(焓)(kJ·mol^-1)：-628.5

32.液相标准热熔(J·mol^-1·K^-1)：258.4

安全信息

外观与性状：

透明液体

密度：

1.118 g/mL at 25 °C(lit.)

熔点：

−10 °C(lit.)

沸点：

245 °C(lit.)

闪点：

143 °C

水溶解性：

SOLUBLE

折射率：

n20/D 1.447(lit.)

蒸汽压：

0.00469mmHg at 25°C

蒸汽密度：

2.14 (vs air)

存储条件/存储方法：

1.密封于阴凉、干燥处保存。确保工作间有良好的通风设施。

2.远离火源、水源。储存的地方远离氧化剂。

稳定性相关：

1.避免与氧化物、潮湿的水分接触。

其它信息：

1.性状：无色、无臭、透明，具有吸湿性的黏稠液体，有辛辣气味，无腐蚀性。

2.沸点（ºC,101.3kPa）：245

3.熔点（ºC）：-10.5

4.相对密度（g/mL,20/4ºC）：1.118

5.相对蒸汽密度（g/mL,空气=1）：2.14

6.折射率（15ºC）：1.4490

7.折射率（20ºC）：1.4472

8.常温折射率（n²⁵）：1.446

9.黏度（mPa·s,20ºC）：35.7

10.黏度（mPa·s,25ºC）：30

11.闪点（ºC,闭口）：143

12.燃点（ºC）：229

13.蒸发热（KJ/mol,b.p.）：52.297

14.燃烧热（KJ/mol）：2380.2

15.比热容（KJ/(kg·K),20ºC,定压）：2.31

16.电导率（S/m,20ºC）：5.86×10^-7

17.蒸气压（kPa,20ºC）：<0.0013

18.体膨胀系数（K^-1,20ºC）：0.000635

19.爆炸下限（%,V/V）：0.7

20.爆炸上限（%,V/V）：22

21.溶解性：能与水、乙醇、乙二醇、丙酮、氯仿、糠醛等混溶。与乙醚、四氯化碳、二硫化碳、直链脂肪烃、芳香烃等不混溶。

22.相对密度（25℃，4℃）：1.1122

23.临界温度（ºC）：476.85

24.临界压力（MPa）：4.7

25.溶度参数(J·cm^-3)^0.5：27.775

26.vanderWaals面积（cm²·mol^-1）：8.920×10⁹

27.vanderWaals体积（cm³·mol^-1）：60.700

28.气相标准燃烧热(焓)(kJ·mol^-1)：-2432.0

29.气相标准声称热(焓)(kJ·mol^-1)：-571.2

30.液相标准燃烧热(焓)(kJ·mol^-1)：-2374.7

31.液相标准声称热(焓)(kJ·mol^-1)：-628.5

32.液相标准热熔(J·mol^-1·K^-1)：258.4

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ID5950000

CHEMICAL NAME :: Diethylene glycol

CAS REGISTRY NUMBER :: 111-46-6

BEILSTEIN REFERENCE NO. :: 0969209

LAST UPDATED :: 199712

DATA ITEMS CITED :: 56

MOLECULAR FORMULA :: C4-H10-O3

MOLECULAR WEIGHT :: 106.14

WISWESSER LINE NOTATION :: Q2O2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

REFERENCE :: 85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,731,1969

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 42,355,1931 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,173,1939

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Liver - other changes Nutritional and Gross Metabolic - metabolic acidosis

REFERENCE :: JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 109,731,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12565 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,25,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,3836,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,3836,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6565 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,25,1974

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7826 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 59,93,1937

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15650 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Gastrointestinal - nausea or vomiting

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(3),16,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 23700 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - muscle weakness Liver - other changes

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 4,142,1945

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 mg/m3/2H

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(12),30,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9719 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Kidney, Ureter, Bladder - changes in both tubules and glomeruli Blood - changes in spleen

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 6,342,1947

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 42,355,1931

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13300 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Gastrointestinal - nausea or vomiting

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(3),16,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 9 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 67,101,1939

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,173,1939

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4400 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,173,1939

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 11890 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,25,1974

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2236 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 59,93,1937

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4472 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 59,93,1937

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2688 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Gastrointestinal - nausea or vomiting

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(3),16,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 7800 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - muscle weakness Liver - other changes

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 4,142,1945

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 14 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Gastrointestinal - nausea or vomiting

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(3),16,1968 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 297 gm/kg/99D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes Related to Chronic Data - death

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,261,1986

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/m3/2H/26W-I

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - emphysema Related to Chronic Data - death

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(12),30,1966

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/m3/11W-I

TOXIC EFFECTS :: Cardiac - other changes Liver - fatty liver degeneration Related to Chronic Data - death

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(12),30,1966

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 105 gm/kg/18D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,261,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 17300 uL/kg/30D-I

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 29,325,1947 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 890 gm/kg/53W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Kidney, Ureter, Bladder - changes in both tubules and glomeruli

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 28,40,1946

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg/82W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Blood - tumors

REFERENCE :: VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications. Volume(issue)/page/year: #6801-83

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 mg/kg/22W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Blood - tumors

REFERENCE :: VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications. Volume(issue)/page/year: #6801-83

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 mg/m3/2H/30W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease Skin and Appendages - tumors

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(2),36,1968

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 mg/kg/66W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Blood - tumors

REFERENCE :: VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications. Volume(issue)/page/year: #6801-83

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1752 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

REFERENCE :: IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5. Volume(issue)/page/year: 36,55,1967

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 584 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 4,149,1945

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 840 mg/kg/81W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Blood - tumors

REFERENCE :: VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications. Volume(issue)/page/year: #6801-83 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 gm/kg

SEX/DURATION :: female 1-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 27,801,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 76420 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0291-1175

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 38212 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0291-1175

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 343 gm/kg

SEX/DURATION :: multigeneration

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Effects on Newborn - sex ratio

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 14,622,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 343 gm/kg

SEX/DURATION :: multigeneration

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Newborn - other postnatal measures or effects

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 14,622,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-159327

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-159327 *** REVIEWS *** TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 23 ppm (100 mg/m3) JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 25544 No. of Facilities: 27975 (estimated) No. of Industries: 222 No. of Occupations: 129 No. of Employees: 273598 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 25544 No. of Facilities: 55518 (estimated) No. of Industries: 292 No. of Occupations: 178 No. of Employees: 890145 (estimated) No. of Female Employees: 261558 (estimated)

毒理学数据：

1、刺激性：兔子经皮：500mg轻度刺激。

兔子经眼：50mg轻度刺激。

2、急性毒性：大鼠经口LD50：12565mg/kg；兔子经皮LD50：11890mg/kg

3、属微毒类。可经皮吸收，对皮肤黏膜刺激小。与乙二醇相似对中枢神经系统有抑制作用。能引起肾脏病理改变及尿路结石。人一次口服致死量估计为1mL/kg。服用二甘醇后约24小时出现恶心、呕吐、腹痛、腹泻等肠胃道症状。致死者随之出现头痛、肾区疼痛、一时性多尿然后少尿、嗜睡、面部轻度浮肿等。无尿发生后2～7日内昏迷而死。故本品应禁作药用，避免长期与皮肤接触。

生态数据：: 对水体有轻微的危害。

MSDS

第一部分：化学品名称

化学品中文名称：	二乙二醇；二甘醇
化学品英文名称：	Diethylene glycol；Diglycol
中文俗名或商品名：
Synonyms：
CAS No.：	111-46-6
分子式：	C₄H₁₀O₃
分子量：	106.12

第二部分：成分/组成信息

纯化学品混合物

化学品名称：二乙二醇；二甘醇

有害物成分

含量

CAS No.

第三部分：危险性概述

危险性类别：
侵入途径：	吸入食入经皮吸收
健康危害：	未见本品引起职业中毒的报道。口服引起恶心、呕吐、腹痛、腹泻及肝、肾损害。可因严重肾损害而致死。
环境危害：
燃爆危险：	本品可燃。

第四部分：急救措施

皮肤接触：	脱去污染的衣着，用大量流动清水彻底冲洗。
眼睛接触：	立即翻开上下眼睑，用流动清水或生理盐水冲洗。
吸入：	脱离现场至空气新鲜处。就医。
食入：	给饮足量温水，催吐，就医。

第五部分：消防措施

危险特性：	遇高热、明火或与氧化剂接触，有引起燃烧的危险。
有害燃烧产物：	一氧化碳、二氧化碳。
灭火方法及灭火剂：	尽可能将容器从火场移至空旷处。喷水保持火场容器冷却，直至灭火结束。处在火场中的容器若已变色或从安全泄压装置中产生声音，必须马上撤离。用水喷射逸出液体，使其稀释成不燃性混合物，并用雾状水保护消防人员。灭火剂：水、雾状水、抗溶性泡沫、干粉、二氧化碳、砂土。
消防员的个体防护：
禁止使用的灭火剂：
闪点(℃)：	124
自燃温度(℃)：	引燃温度(℃)：228
爆炸下限[%(V/V)]：	无资料
爆炸上限[%(V/V)]：	无资料
最小点火能(mJ)：
爆燃点：
爆速：
最大燃爆压力(MPa)：
建规火险分级：

第六部分：泄漏应急处理

应急处理：

迅速撤离泄漏污染区人员至安全区，并进行隔离，严格限制出入。切断火源。建议应急处理人员戴自吸过滤式防毒面具（全面罩），穿防毒服。尽可能切断泄漏源。防止流入下水道、排洪沟等限制性空间。小量泄漏：用砂土、蛭石或其它惰性材料吸收。也可以用大量水冲洗，洗水稀释后放入废水系统。大量泄漏：构筑围堤或挖坑收容。用泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。

第七部分：操作处置与储存

操作注意事项：

密闭操作，注意通风。操作人员必须经过专门培训，严格遵守操作规程。建议操作人员佩戴自吸过滤式防毒面具（半面罩），戴化学安全防护眼镜，穿防毒物渗透工作服，戴防化学品手套。远离火种、热源，工作场所严禁吸烟。使用防爆型的通风系统和设备。防止蒸气泄漏到工作场所空气中。避免与氧化剂、酸类接触。搬运时轻装轻卸，防止包装破损。配备相应品种和数量的消防器材及泄漏应急处理设备。倒空的容器可能残留有害物。

储存注意事项：

储存于阴凉、通风的库房。远离火种、热源。应与氧化剂、酸类分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有泄漏应急处理设备和合适的收容材料。

第八部分：接触控制/个体防护

最高容许浓度：	中国 MAC：未制订标准前苏联MAC：10mg／m3 美国TLV—TWA：未制订标准
监测方法：
工程控制：	密闭操作，注意通风。
呼吸系统防护：	空气中浓度超标时，应该佩戴防毒面具。
眼睛防护：	必要时戴安全防护眼镜。
身体防护：	穿工作服。
手防护：	戴防化学品手套。
其他防护：	工作现场严禁吸烟。避免长期反复接触。定期体检。保持良好的卫生习惯。

第九部分：理化特性

外观与性状：	无色、无臭、开始味甜回味苦的粘稠液体，具有吸湿性。
pH：
熔点(℃)：	-8．0
沸点(℃)：	245．8
相对密度(水=1)：	1．12(20℃)
相对蒸气密度(空气=1)：	3．66
饱和蒸气压(kPa)：	0．13(91．8℃)
燃烧热(kJ/mol)：
临界温度(℃)：
临界压力(MPa)：
辛醇/水分配系数的对数值：
闪点(℃)：	124
引燃温度(℃)：	引燃温度(℃)：228
爆炸上限%(V/V)：	无资料
爆炸下限%(V/V)：	无资料
分子式：	C₄H₁₀O₃
分子量：	106.12
蒸发速率：
粘性：
溶解性：	与水混溶，不溶于苯、甲苯、四氯化碳。
主要用途：	用作人造丝的软化剂和烟草的湿润剂，还是某些化工产品的中间体，也用作汽车发动机防冻剂、刹车油等。

第十部分：稳定性和反应活性

稳定性：	在常温常压下稳定
禁配物：	强氧化剂、强酸。
避免接触的条件：
聚合危害：	不能出现
分解产物：	一氧化碳、二氧化碳。

第十一部分：毒理学资料

急性毒性：	LD50：16600mg／kg(大鼠经口)；26500mg／kg(小鼠经口) LC50：
急性中毒：
慢性中毒：
亚急性和慢性毒性：
刺激性：
致敏性：
致突变性：
致畸性：
致癌性：

第十二部分：生态学资料

生态毒理毒性：
生物降解性：
非生物降解性：
生物富集或生物积累性：

第十三部分：废弃处置

废弃物性质：
废弃处置方法：	处置前应参阅国家和地方有关法规。建议用焚烧法处置。
废弃注意事项：

第十四部分：运输信息

危险货物编号：
UN编号：
包装标志：
包装类别：
包装方法：
运输注意事项：	运输前应先检查包装容器是否完整、密封，运输过程中要确保容器不泄漏、不倒塌、不坠落、不损坏。严禁与氧化剂、酸类等混装混运。船运时，应与机舱、电源、火源等部位隔离。公路运输时要按规定路线行驶。
RETCS号：
IMDG规则页码：

第十五部分：法规信息

国内化学品安全管理法规：
国际化学品安全管理法规：

第十六部分：其他信息

参考文献：	1.周国泰，化学危险品安全技术全书，化学工业出版社，1997 2.国家环保局有毒化学品管理办公室、北京化工研究院合编，化学品毒性法规环境数据手册，中国环境科学出版社.1992 3.Canadian Centre for Occupational Health and Safety,CHEMINFO Database.1998 4.Canadian Centre for Occupational Health and Safety, RTECS Database, 1989
填表时间：	年月日
填表部门：
数据审核单位：
修改说明：
其他信息：	3
MSDS修改日期：	年月日

海关数据

中国海关编码：2909410000

概述：: 2909410000 2,2'-氧联二乙醇(二甘醇)。监管条件:无。增值税率:17.0%。退税率:9.0%。最低关税:5.5%。普通关税:30.0%
申报要素：: 品名, 成分含量, 用途
摘要/Summary：: 2909410000 2,2'-oxydiethanol。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0%

分子结构与计算化学数据

分子结构数据

1、摩尔折射率：25.39

2、摩尔体积（cm³/mol）：95.9

3、等张比容（90.2K）：244.4

4、表面张力（dyne/cm）：42.1

5、极化率（10^-24cm³）：10.06

计算化学数据

1.疏水参数计算参考值（XlogP）:-1.3

2.氢键供体数量:2

3.氢键受体数量:3

4.可旋转化学键数量:4

5.互变异构体数量:无

6.拓扑分子极性表面积49.7

7.重原子数量:7

8.表面电荷:0

9.复杂度:26.1

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1